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New medical technique helps men with no sperm become fathers

Hung Vuong Hospital has performed a technique using immature sperm and mature eggs for two fathers who cannot produce sperm.

M, 35, was diagnosed with Klinefelter syndrome, a chromosomal abnormality that results in no sperm. 

The completely new technique called ROSI injects immature sperm into cytoplasm.

M. received internal medicine treatment at Binh Dan Hospital before the operation. This created endocrine indexes closest to normal values. In general, this is carried out at least two months before surgery to find sperm to increase the success rate. At the same time, he was also given genetic testing.

Dr Mai Ba Tien Dung, Head of Andrology Department of Binh Dan Hospital, performed microdissection to find sperm, and the rate was over 63 percent. The technique required a microscope with appropriate magnification, microsurgery instruments, a fertility assistant lab, and highly specialized personnel.

After receiving the sperm from the Binh Dan Hospital, Ly Thai Loc of Hung Vuong Hospital and his co-workers began the process of seeking immature sperm.

Tan Kim Hoang Van, an embryologist of Hung Vuong Hospital, under the microscope with super-large magnification, could find immature healthy sperm which could be injected into the mother’s cytoplasm.

“Both andrology doctors and embryologists needed to work together because if eggs and sperm are taken early and kept frozen, the success rate will be lower,” Van explained.

“We had to calculate and perform certain skills so that immature sperm and mature eggs ‘accept’ each other to develop an embryo. This work was more difficult than harmonizing mature sperm and eggs,” he said.

In the case of M, as the patient has a chromosomal abnormality syndrome, after the embryo creation, it was necessary to select embryos without chromosomal abnormalities, which was also a challenge. Luckily, doctors and embryologists could find normal embryos to inject into the wife’s body.

L, born in 1991, the wife of M, had a normal gestation period and she is being cared for like other pregnant women. Meanwhile, the unused embryos are being stored for the next time.

The other success story is the case of TM and P. After great efforts, M became pregnant.

“These are the first two cases of infertility successfully treated at the hospital thanks to the ROSI technique and they are also the first in Vietnam,” said Dr Hoang Thi Diem Tuyet, Director of Hung Vuong Hospital.

Linh Giao


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